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| FYVE finger-containing phosphoinositide kinase ： ウィキペディア英語版 |
PIKFYVE
PIKfyve, a FYVE finger-containing phosphoinositide kinase, is an enzyme that in humans is encoded by the ''PIKFYVE'' gene.〔〔
== Function ==
The principal enzymatic activity of PIKfyve is to phosphorylate PtdIns3P to PtdIns(3,5)P2. PIKfyve activity is responsible for the production of both PtdIns(3,5)P2 and phosphatidylinositol 5-phosphate (PtdIns5P).〔Sbrissa D, Ikonomov OC, Deeb R, Shisheva A. "Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells. ''J Biol Chem.'' 2002;277(49):47276-84. PMID 12270933〕 PIKfyve is a large protein, containing a number of functional domains and expressed in several spliced forms. The reported full-length mouse and human cDNA clones encode proteins of 2052 and 2098 amino acid residues, respectively.〔〔〔〔 By directly binding membrane PtdIns(3)P,〔 the FYVE finger domain of PIKfyve is essential in localizing the protein to the cytosolic leaflet of endosomes.〔〔 Impaired PIKfyve enzymatic activity by dominant-interfering mutants, siRNA- mediated ablation or pharmacological inhibition causes endosome enlargement and cytoplasmic vacuolation due to impaired PtdIns(3,5)P2 synthesis. Thus, via PtdIns(3,5)P2 production, PIKfyve participates in several aspects of endosome dynamics,〔〔 thereby affecting a number of trafficking pathways that emanate from or traverse the endosomal system en route to the trans-Golgi network or later compartments along the endocytic pathway.〔〔〔〔〔〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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